Abstract

It is a herbal medicine that is commonly used in the treatment of sinusitis among the people in the Mediterranean region of Ecballium elaterium, and has many pharmacological uses. The main therapeutic application for the treatment of Alzheimers disease is the inhibition of AChE and BChE, i.e., cholinesterase enzymes. AChE and BChE are hydrolytic enzymes that hydrolyze the neurotransmitter acetylcholine. There are many active substances in painful heifers and it is very costly and time-consuming to isolate and investigate their individual activities. In order to shorten the process and eliminate the cost, the molecular bonding energies of some active substances in AChE and BChE were determined to determine the chemical activity of the molecules and the inhibitory effect on AChE and BChE by using the docking method related to the interactions and inhibition effects of the molecules, which have recently yielded very close results with experimental studies. theoretically compared.

References

[1] Attard,E., Attard,H., Cucurbit Genetics Cooperative Report 2002, 25: 67-70..
[2] Abbassi F., Ayari B., Mhamdi B., Toumi L., Pak J Pharm Sci,. 2014,27(3), 475-479.
[3] Ercan,P., El,S.N., International Journal of Biological Macromolecules 2018,115, 933–939.
[4] Zengina,G., Senkardes, Mollicac, Picot-Allaind, C.M.N.,Bulut, G.,Dogan, A.,M.,Mahomoodally,F., Computational Biology and Chemistry 2018,75 ,111–119.
[5] Ekici, M.,Satılmış,A., Ay,D.Y., the study of the effects of ecballium elaterium (l.) insinusites, Ecology Environment Journal, 1998, 7-27, 24-25.
[6] Orhan,İ.E., Senol,F.S., Haznedaroglu,M.Z., Koyu,H., Erdem,S.A., Yılmaz,G., Cicek,M.,Yaprak,A.E., Ari,E., Kucukboyaci,N., Toker,G., Neurobiological evaluation of thirty-onemedicinal plant extracts using microtiter enzyme assays, Clinical Phytoscience 2016, 2:9.
[7] Güllü,İ.B. Öcal, N.,Tıbbi bir bitki olarak Ecballium elaterium (L.)’un tedavi alanlarınınaraştırılması, BAUN Fen Bil. Enst. Dergisi, 2016, 18(1), 49-57.
[8] Bikadi, Z., Hazai, E., PM6 yarı-ampirik yönteminin proteinlerin modellenmesineuygulanması, AutoDock J. Cheminf. 2009, 1, 15.