Abstract

Hydroxyapatite (HA) is widely used in biomedical implant applications, due to its bioactive, biodegradable and osteoconductive properties. The fabrication of HA by chemical routes is fairly complicated. Extraction of HA from the bovine bone is economic and bio compatible and besides it is easy to obtain. The HA extracted from the bovine bone have most properties of the origin bone. In addition to this, bone grafting potential is better than HA produced by chemical route. The aim of this work is to understand sintering/densification behavior of HA produced from bovine bone (by Archimedes principle kit), the microstructure of the sintered bodies (by SEM-EDS) and their mechanical properties (hardness and fractured toughness). Densifications of compact HA samples from natural bone with and without additive were investigated. Phase identification of the raw cow bone and sintered compacts were determined by X-ray diffraction technique.

References

[1] P. Mulinti, et al., Hemocompatibility of Biomaterials for Clinical Applications, 2018].
[2] Ito K, Yamada Y, Nagasaka T, Baba S, Ueda M. Osteogenic potential of injectable tissueengineered bone: a comparison among autogenous bone, bone substitute (Bio-oss), plateletrich plasma, and tissue-engineered bone with respect to their mechanical properties andhistological findings. J Biomed Mater Res A 2005;73:63-72.]
[3] d'Haese R., Pawlowski L., Bigan M., et al., Phase evolution of hydroxapatite coatings suspension plasma sprayed using variable parameters in simulated body fluid, Surface &Coatings Technology 204 (2010) 1236–1246
[4] Williams D.F., Biomaterials 29 (2008) 2941.
[5] Yang, Y. Kim, K.-H. K.-H. Ong, J.L., Biomaterials 26 (2005) 327.
[6] Elliott JC. Structure and chemistry of the apatites and other calcium orthophosphates.In:Studies in inorganic chemistry, vol. 18. Amsterdam: Elsevier;1994..
[7] Czarnowska, E. Zajaczkowska, A. . Godlewski, M.M., Mroz, W., J. Nanosci.Nanotechnol. 8(2008) 1.
[8] LeGeros R.Z., in: P.W. Brown, B. Constanz (Eds.), Hydroxyapatite and Related Materials,CRC Press, Boca Raton, 1994, pp. 3–28.
[4] R.Z. LeGeros, Calcium Phosphates in OralBiology and Medicine, Karger, Basel,1991
[9] Cacciotti, I., et al. Mg-substituted hydroxyapatite nanopowders: Synthesis, thermal stabilityand sintering behaviour , Journal of the European Ceramic Society 29 (2009) 2969–2978
[10] Chang, E., Chang, W.J., Yang, C.Y., Mater. Sci. Mater. Med. 8 (1997) 193
[11] Suchanek W., Yoshimura M., Processing and properties of hydroxyapatite-basedbiomaterials as hard tissue replacement implants. J Mater Res 1998;13:94–117.
[12] Ming-Jie J., Xiao-Xiang W., Electrolytic deposition of magnesium-substitutedhydroxyapatite crystals on titanium substrate, Materials Letters 63 (2009) 2286–2289
[13] LeGeros RZ., Properties of osteoconductive biomaterials: calcium phosphates. Clin OrthopRelat Res 2002;395:81–9.